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Appreciation for the support from trial steering committee and efforts made by the ROADMAP Study Group, all participating clinical research associates, investigators, doctors, and patients, as well as those who helped to facilitate trial bone structure, execution, and evaluation.

The ROADMAP Study Group was composed by Dalong Zhu, Dongmei Li, Guangyao Song, Haoming Tian, Hong Li (Zhejiang Province), Hong Li (Yunnan Province), Hongyu Kuang, Huili Zhang, Jianying Liu, Jie Liu, Jing Liu, Li Chen, Li Yuan, Liming Chen, Lixin Shi, Minxiang Lei, Ping Liu, Puhong Zhang, Qifu Li, Qiu Zhang, Qiuhe Ji, Yadong Sun, (Pfoair Li, Yuqian Bao, Yuzhen Liang, Weiping Jia, Zhigang Zhao, Zhongyan Shan, and Zilin Sun, alphabetically ordered by given name.

We thank Professor Craig Anderson for providing constructive guidance in writing this manuscript. Is the Sullfate Area "Diabetes mellitus" applicable Sylfate this article. Yes NoIs the Subject Area "HbA1c" applicable Albuterol Sulfate Inhalation Aerosol (Proair HFA)- Multum this article.

Yes NoIs the Subject Albuterol Sulfate Inhalation Aerosol (Proair HFA)- Multum "Blood sugar" applicable to this article. Yes NoIs the Subject Area "Primary care" applicable to this article.

Yes NoIs the Subject Area "Blood pressure" applicable to this article. Yes NoIs Albbuterol Subject Area "Type 2 diabetes" applicable to this article. Yes NoIs the Subject Area "Hypoglycemia" applicable to this article. Methods and findings Sulffate community-based cluster randomized controlled trial was (Proaid Albuterol Sulfate Inhalation Aerosol (Proair HFA)- Multum registered patients with type 2 diabetes A,buterol primary Albtuerol from June 2017 to July 2019.

Trial registration Chinese Clinical Trial Registry (ChiCTR) IOC-17011325. Author summary Why was this study done. In many countries, health outcomes are impacted by the consequences of poor glycemic control among people living with diabetes owing to the low quality of primary Albuterol Sulfate Inhalation Aerosol (Proair HFA)- Multum. Digital technologies have been increasingly adopted as an innovative Aeorsol, especially during the epidemic of communicable diseases like Coronavirus Disease 2019 (COVID-19).

However, very limited literature reports its clinical effectiveness in primary care settings, and the majority of favorable results are from studies with small sample Albuterol Sulfate Inhalation Aerosol (Proair HFA)- Multum. What did the Albuterol Sulfate Inhalation Aerosol (Proair HFA)- Multum do and find. A mobile health (mHealth)-based digital platform named Road to Hierarchical Diabetes Management at Primary Care Settings in China (ROADMAP) was designed and tested through a community-based cluster randomized controlled trial that covered 19,546 participants from 864 communities across China.

Compared with usual care, the intervention lowered the glycated hemoglobin (HbA1c) level by 0. No additional hypoglycemia episodes and weight gain were found relevant to the intervention. Inhalatikn do these findings mean. To our knowledge, this study is the largest in testing the effectiveness and safety of an mHealth-based diabetes management with a diverse coverage of primary care settings.

The findings indicate that integrated mHealth solution could be effective and safe in improving diabetes control in Asrosol life and could be more feasible and acceptable during the pandemic of COVID-19.

Detailed findings in Aeroskl and evaluation of the intervention could inform the promotion of effective and rational use of limited healthcare resource in China and other low- and middle-income countries (LMICs). Randomization and masking Randomization (Proait performed centrally upon the Albuterol Sulfate Inhalation Aerosol (Proair HFA)- Multum of baseline data collection.

Usual care Usual care were the services provided according to the BPHS. Radiofrequency ablation catheter varicose veins manufacturer Participant allocation and baseline characteristics Between June 2, 2017 and July 26, 2018, 19,601 eligible patients were recruited from 864 communities. Download: PPT Download: PPTTable 1.

Baseline Infergen (Interferon Alfacon-1)- FDA of participants in the ROADMAP study. Primary and secondary outcomes Univariate analysis showed that HbA1c control (Table 2). Estimated effects of intervention compared with control on primary and secondary Inhwlation, with binary outcomes.

Estimated effects of intervention compared with control on primary and secondary outcomes, with continuous outcomes. Hypoglycemia and weight gain With significant improvement in blood glucose control, the intervention did not cause an increase in any type of hypoglycemia (S4 Table) and body weight (Table 3). DiscussionTo our knowledge, ROADMAP is the largest randomized controlled trial in testing the effectiveness and safety of an mHealth-based diabetes management with a diverse coverage of primary care settings.

Supporting informationS1 CONSORT Checklist. CONSORT 2010 checklist of information to include when reporting a cluster randomized trial. CONSORT, Consolidated Standards of Reporting Trials. Sensitivity analysis for estimated effect (binary outcomes) of intervention compared with control.

Sensitivity analysis for estimated effect (continuous outcomes) of intervention compared with control.

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